Localized Intolerance Model using Bayesian Regression (LIMBR) is a sub-regional (domains or exons) genic intolerance score. Above is a per gene plot where on top is the intolerance score, where lower raw score or percentile scores indicates that a region is less intolerant to variation and more likely to be under negative selection. On bottom are the total ClinVar pathogenic variants across each sub-region.
For more details please see about or our article: Improved pathogenic variant localization via a hierarchical model of sub-regional intolerance
Hayeck, T. J., Stong, N., Wolock, C. J., Copeland, B., Kamalakaran, S., Goldstein, D. B., & Allen, A. S. (2019). Improved pathogenic variant localization via a hierarchical model of sub-regional intolerance. The American Journal of Human Genetics, 104(2), 299-309.